Greek's Pizzeria was founded in 1968 by Athanasios "Chris" Karamesines, who set out to fulfill his dream of becoming a pizza restaurateur. Born in Chicago, Chris developed a taste for good food at a young age and was influenced by his father, who traveled to the United States from Greece in 1919. The Karamesines family has been in the restaurant business since 1922, and Chris opened his first restaurant at the age of 14.

Chris later became a self-taught professor of pizza, earning his home-baked degree by studying in the kitchens of top-notch operations across the country. He opened his first pizzeria, Greek's Pizzeria, at the age of 17 in Valparaiso, Indiana. Over the years, Chris and his wife, Cindy, built more than 140 pizza restaurants in several states, including Indiana, Hawaii, Florida, Pennsylvania, Kansas, Texas, and Ohio.

Today, Greek's Pizzeria is a one-member LLC, not a shareholder, partnership, or publicly owned company. The restaurants feature specialized pizzas, pastas, fresh French-style bread sandwiches, pizza shell wraps, breadsticks, salads, and an assortment of beverages. Greek's Pizzeria locations are independently, locally-owned and operated, and the company continues to grow, with a focus on its signature taste and method of preparation that has made its pizzas more flavorful and original than others.